Clinical study of MRP and LRP mRNA expression in peple with human non-small cell lung cancer after cisplatin chemotherapy
- VernacularTitle:晚期非小细胞肺癌患者应用顺铂化疗后MRP和LRP基因表达的临床研究
- Author:
Zhijun WEN
- Publication Type:Journal Article
- Keywords:
non small-cell lung cancer;
cis-platinum complexes;
multidrug resistance associated protein;
lung resistance protein
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):108-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mRNA expression of the multidrug resistance associated protein and lung resistance protein in human non-small cell lung cancer tissues and their relationship with cis-platinum. Methods 13 samples were collected from patients with non small cell lung cancer before and after chemotherapy, the mRNA expression of MRP and LRP were detected using RT-PCR method, correlation between two genes were studied by Logistic regression analysis. Results Compared with before cisplatin chemotherapy, MRP and LRP expression of patients were increased after chemotherapy(P<0.05).Logistic regression analysis showed that there is no correlation between the two genes(r=0.036,P<0.05). Conclusion Cisplatin chemotherapy can increase the mRNA expression of MRP and LRP, and there is no correlation between the two genes.
