Effects of glutamine combined with early enteral nutrition on severe acute pancreatitis’ systemic inlfammation
- VernacularTitle:谷氨酰胺联合早期肠内营养对急性重症胰腺炎全身炎症的影响
- Author:
Guoxiang YANG
;
Wanli ZHANG
;
Hansong DU
;
Ronglin ZHAI
;
Li QIU
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
early enteral nutrition;
glutamine;
systemic inlfammation
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the glutamine combined with early enteral nutrition’s effects on severe acute pancreatitis’systemic inlfammation. Methods 150 Cases with severe acute pancreatitis were divided into total parenteral nutrtion group(TPN group), early enteral nutrition group(EEN group) and Glutamine and early enteral nutrition group(G+EEN group) according to their therapeutic methods. The curative effects, APACHEⅡscore and liver and kidney function were compared after treatment. Inlfammatory cytokines of hs-CRP, TNF-α, IL-1β, IL-6, IL-8 and IL-10 before and after treatment were detected and compared. Results The efifciency rate in G+EEN group was signiifcantly better than that in TPN and EEN group(P<0.05), with lower APACHEⅡscore and better liver and kidney function. The level of hs-CRP, TNF-α, IL-1β, II-6 and IL-8 after treatment in G+EEN group were signiifcantly lower than that in TPN and EEN group(P<0.05), except IL-10, which was signiifcantly higher than that in TPN and EEN group (P<0.05). Conclusion Glutamine combined with early enteral nutrition could signiifcantly ameliorate severe acute pancreatitis’systemic inlfammation, its curative effects is better than early enteral nutrition and total parenteral nutrition.
