The study of the potassium ion channel Kv 3 .4 in buccal mucosa carcinogenesis of rat
10.3969/j.issn.1671-8348.2014.15.005
- VernacularTitle:钾离子通道Kv3．4在大鼠颊黏膜癌变中的表达研究
- Author:
Chengcheng SONG
;
Junjiao ZHOU
;
Baoqin WU
;
Minhai NIE
- Publication Type:Journal Article
- Keywords:
Kv3 .4;
oral squamous cell carcinoma;
immunohistochemistry;
RT-PCR
- From:
Chongqing Medicine
2014;(15):1837-1839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of the Kv3 .4 protein and Kv3 .4 mRNA in various stages of oral carcino‐genesis .Methods The expression of Kv3 .4 protein and Kv3 .4 mRNA were detected by immunohistochemistry (SP method) and RT‐PCR technique respectively in the oral carcinogenesis of SD rat which were induced by 4NQO .Results With the aggravation of the epithelial dysplasia ,Kv3 .4 protein and Kv3 .4 mRNA expression increased gradually .They were strongly positive in oral squa‐mous cell carcinoma .Conclusion The expression of Kv3 .4 protein and Kv3 .4 mRNA levels increased consistently with the aggra‐vation of the epithelial dysplasia .
