Experimental study on the effect of Jiawei Siwu Decoction on thrombocytopenia purpura in mice
10.3969/j.issn.1671-8348.2014.15.022
- VernacularTitle:加味四物汤对血小板减少性紫癜小鼠影响的实验研究
- Author:
Xiaoyan FENG
;
Hong GU
;
Changfu YANG
;
Jiannan SHI
;
Luping YAN
- Publication Type:Journal Article
- Keywords:
parpura,thrombocytopenia,idopathic;
Jianwei Siwu Decoction;
interleukin-6;
nucleated cell of marrow;
spleen index
- From:
Chongqing Medicine
2014;(15):1886-1888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Jiawei Siwu Decoction for idiopathic thrombocytopenic purpura (ITP) on the effi‐cacy and immune aspects of the model mice .Methods We used guinea pig anti mouse platelet serum immune IT P model ,then con‐duct the corresponding drug treatment .The mice were observed in peripheral blood ,bone marrow changes of nuclear cell count ,ser‐um IL‐6 content and changes in the spleen index .Results Compared with the model group of physiological saline of peripheral blood WBC ,prednisone group and Chinese medicine group PLT count ,bone marrow nucleated cell counts were significantly elevated (P<0 .01) ,the content of IL‐6 in serum were increased significantly (P<0 .01) ,no difference between the two treatment groups . Thymus and spleen index increased too (P<0 .05) .Conclusion Jiawei Siwu Decoction may be related to the regulation of cellular immunity ,increased serum IL‐6 content ,improve bone marrow hematopoietic microenvironment to achieve therapeutic effects in the ITP mice .
