Mechanism of Ulinastat’s enhancement for antibiotics' curative effects in sepsis children caused by bacteria
- VernacularTitle:乌司他丁增强抗生素治疗儿童细菌致脓毒血症疗效的机制研究
- Author:
Simin ZHANG
;
Jun XU
;
Junhua LI
- Publication Type:Journal Article
- Keywords:
sepsis;
ulinastat;
inlfammatory factors
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):125-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of Ulinastat’s enhancement for antibiotics’curative effects in sepsis Children caused by bacteria. Methods Children with sepsis caused by bacteria were treated with Ulinastat combined with antibiotics (UTI group) and antibiotics only (CON group), The curative effects, GSC scores and APACHEⅡscores in two groups were observed and compared, pre-and post-therapy serum procalcitonin and inlfammatory factors were detected and compared. Results The efifciency rate and GSC score in UTI group were signiifcantly higher than in CON group (P<0.05), but lower in mortality and APACHEⅡscore (P<0.05). hs-CRP, TNF-α, IL-6 and IL-8 of UTI group in one week, two weeks and three weeks post-therapy were signiifcantly lower than in CON group (P<0.05), while IL-10 was higher(P<0.05). Conclusion The Ulinastat can signiifcantly increases antibiotics’curative effects for sepsis Children caused by bacteria though lowering down serum PCT, hs-CRP, TNF-α, IL-6 and IL-8 and increasing IL-10.
