Factors influencing the treatment effect of cancer pain in patients with moderate and severe chronic pain
10.3969/j.issn.1000-8179.20132077
- VernacularTitle:影响慢性中重度癌痛患者疼痛治疗效果的相关因素分析
- Author:
Nanya WANG
;
Yumei LIU
;
Hengjun ZHAO
;
Hua HE
;
Wei LI
- Publication Type:Journal Article
- Keywords:
cancer pain;
breakthrough pain;
bone metastases;
neuropathic pain
- From:
Chinese Journal of Clinical Oncology
2014;(10):655-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to analyze the factors affecting the outcome of cancer pain in patients with moderate and severe chronic cancer pain for clinical decision making. Methods: Data were collected from 426 cancer patients with moderate and severe chronic cancer pain, and the factors affecting pain treatment were analyzed. Results:A total of 85.6%of patients had good pain control in 3 days (NRS≤3). Multivariate logistic regression models showed that the pain of patients with bone metastases (P=0.026), breakthrough pain after stable pain control (P<0.001), and high MEDD (P<0.001) was poorly controlled. Moreover, age, sex, TNM stage, cause of pain, and medication ladder were not risk factors of pain control (P>0.05). Opioid combination with NSAIDs contributed to easier pain control (P=0.024). Digestive system tumors, pain intensity, limb pain, neuropathic pain, use of transdermal fentanyl matrix patch, multiple metastases in stage-IV patients were suggested to be risk factors of pain control in univariate logistic regression models (P<0.05). Conclusion: Bone metastases, breakthrough pain after pain relief, and high dose of MEDD were independent risk factors. Opioid combination with NSAIDs was a protective factor of pain control.
