Serum levels of inflammatory cytokines in Parkinson′s disease and their clinical significance
10.3969/j.issn.1671-8348.2014.15.009
- VernacularTitle:帕金森病患者血清炎症因子水平及其临床意义
- Author:
Yeran WANG
;
Xiuqing YAO
;
Yanjiang WANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
interleukin-1β;
interleukin-6;
tumor necrosis factor-alpha;
interferon type Ⅱ
- From:
Chongqing Medicine
2014;(15):1848-1850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the serum levels of interleukin(IL)‐1β,IL‐6 ,tumor necrosis factor alpha(TNF‐α) and inter‐feron gamma(IFN‐γ) in patients with Parkinson′s disease(PD) and healthy controls .To analyze the correlations of serum inflamma‐tory factors with disease duration and severity .Methods Peripheral blood samples were collected from 56 PD patients and 120 healthy controls .Serum levels of IL‐1β,IL‐6 ,TNF‐αand IFN‐γwere measured using highly sensitive enzyme linked immunosorbent assay(ELISA) kits .Results Serum levels of IL‐1β,IL‐6 ,TNF‐α were significantly higher in PD patients than in healthy controls (all P<0 .01) ,serum levels of IFN‐γ were not significantly different between PD patients and healthy controls (P=0 .86) .Serum levels of these inflammatory cytokines were not significantly correlated with the disease ,duration ,Hoen & Yahr ,Schwab & Eng‐land scores(P>0 .05) .Conclusion Our results indicate that serum inflammatory factors are altered in PD patients .However ,serum inflammatory factors were not correlated with disease duration and severity .
