Effect of sulodexide combined with dipyridamole on postoperative period of internal arteriovenous fistulae in patients with chronic renal failure complicating diabetes
10.3969/j.issn.1671-8348.2014.15.014
- VernacularTitle:舒洛地特联合双嘧达莫对慢性肾衰竭合并糖尿病患者动静脉内瘘术后的影响
- Author:
Nan OUYANG
;
Ziming WAN
;
Zhengrong LI
;
Xiaogang DU
- Publication Type:Journal Article
- Keywords:
kidney failure,chronic;
diabetes;
internal arteriovenous fistulae;
sulodexide;
dipyridamole
- From:
Chongqing Medicine
2014;(15):1863-1865
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of sulodexide combined with dipyridamole on postoperative period of internal arterio‐venous fistula in the patients with chronic renal failure complicating diabetes .Methods 72 cases of chronic renal failure complica‐ting diabetes were randomly divided into two groups :sulodexide combined with dipyridamole group(group A) and dipyridamole group (group B) .Platelet ,fibrinogen(FIB) ,prothrombin time ,activated partial thromboplastin time ,triglyceride ,total cholesterol and hemortheological indexes were tested at different time points .The internal fistula patency ,blood flow volume after internal fis‐tula maturation and time of initial internal fistula use after internal arteriovenous fistula operationwere observed .‐Results (1)The patency rate of internal arteriovenous fistula in the group A was higher than that in the group B .(2) Compared with the group B , FIB and low‐shear rate of whole blood viscosity in the group A were decreased .(3)The time of internal fistula maturation in the group A was shortened ,but the blood flow volume had no significant difference between the two groups .Conclusion Sulodexide combined with dipyridamole is safe and effective for preventing the thrombogenesis after internal arteriovenous fistula operation ,its effect is superior to single dipyridamole .
