Evaluation of the effect and safety of intravesical perfusion of theprubicin on postoperative recurrence of normuscle invasive bladder cancer
10.3760/cma.j.issn.1008-6706.2014.10.016
- VernacularTitle:吡柔比星膀胱灌注预防膀胱癌术后复发的效果分析
- Author:
Zhihong CAO
;
Guobao ZHOU
;
Yunhan YU
- Publication Type:Journal Article
- Keywords:
Theprubicin;
Intravesical perfusion;
Normuscle invasive bladder cancer;
Recurrence
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(10):1477-1478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and safety of intravesical perfusion of theprubicin ( THP) on postoperative recurrence of normuscle invasive bladder cancer .Methods According to digital table , a total of 58 cases received bladder cancer surgery were randomly divided into observation group and control group .All patients were treated by TURBt surgery .Patients in observation group were treated by THP intravesical perfusion , while patients in control group were treated by intravesical perfusion of mitomycin ( MMC) .A 1-year follow-up was conduc-ted to evaluate the recurrence rate and the toxicity .Results The recurrence rate of observation group in the follow-up period was 10.3%,while the control group was 20.7%,the difference was significant (χ2 =13.880,P<0.05).The incidence rate of toxicity of the observation group was 24.1%,which was lower than 27.5%of the control group ,but the difference was not significant (χ2 =0.090,P>0.05).The incidence rate of Ⅱ-Ⅲgrade toxicity in the observation group was 6.8%,while the control group was 17.2%,the difference was significant (χ2 =16.960,P <0.05). Conclusion The THP intravesical perfusion can prevent postoperative recurrence of normuscle invasive bladder cancer,with less toxicity.THP is effective,safe and reliable.
