The expressions of PTEN,Survivin in tissues of non-small cell lung cancer and its relationship with microvas-cular density
10.3760/cma.j.issn.1008-6706.2014.10.028
- VernacularTitle:PTEN、Survivin 在非小细胞肺癌组织中的表达及其与微血管密度的关系
- Author:
Zheng CAO
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Oncogenes;
Microvessels
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(10):1502-1504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of PTEN ,Survivin in tissues of non-small cell lung cancer and their relationship with microvascular density ( MVD) .Methods 66 cancerous tissues of non-small cell lung canc-er were selected as the observation group ,and adjacent tissues were selected as the control group .PTEN,Survivin and MVD were determined by immunohistochemical staining .Results 17 cases(25.8%) were PTEN positive in the ob-servation group,51 cases(77.3%) were PTEN positive in the control group ,there was significant difference between the two groups(χ2=6.92,P<0.05).Survivin positive expression was 48 cases(72.7%) in the observation group, which was significantly higher than 12 cases(18.2%) in the control group(χ2 =5.72,P<0.05).MVD value was (74.6 ±18.3) in the observation group,which was significantly higher than (23.5 ±6.1) in the control group(t=6.722,P<0.01).There was no significant relationship between PTEN ,Survivin expression and gender ,histological type(χ2 =0.16,0.27,0.22,0.24,all P>0.05),and PTEN,Survivin expression had close relationship with tumor differentiation,lymph node metastasis and distant metastasis (χ2 =4.39,4.92,5.76,5.29,6.26,4.25, all P <0.05).PTEN was negatively correlated with MVD (r=-0.393,P<0.05).Survivin was positively correlated with MVD(r=0.544,P<0.05).Conclusion Low expression of PTEN and overexpression of Survivin are related with the occurrence and development of non-small cell lung cancer .
