Study on diffusion-weighted imaging as a predictive marker for chemoradiotherapy response in cervical canc-er patients
10.3760/cma.j.issn.1008-6706.2014.09.012
- VernacularTitle:扩散加权成像预测宫颈癌放化疗反应的研究
- Author:
Shunzhuang ZHANG
;
Zhoupeng MA
;
Yongxing MIAO
;
Jianjun ZHOU
- Publication Type:Journal Article
- Keywords:
Magnetic Resonance Imaging;
Chemoradiotherapy;
Uterine Cervical Neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(9):1305-1306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between diffusion-weighted imaging ( DWI) characteristics and chemoradiotherapy response in recurrence patients with radical hysterectomy .Methods 26 recurrence patients with radical hysterectomy were included .All underwent conventional MRI and DWI before and after chemoradiotherapy . Baseline tumor characteristics including recurrence site ,gross tumor volume ,necrotic area and the ADC value were re-corded.Focal regions of restricted diffusion were delineated as a separate ROI and ADC value was determined .Ima-ging features were compared between complete response group and partial response group .Results 12 patients had complete response ( CR group ) ,14 patients had partial response ( PR group ) .ADC valueafter chemoradiotherapy was significantly higher than that before chemoradiotherapy in PR patients .Compared with CR group ,PR group had a grea-ter gross tumor volume ,higher ADC value and more focal regions of restricted diffusion .Recurrence type and necrotic areas was no significant differences .Conclusion ADC value and focal regions of restricted diffusion adquired by DWI help to determine chemoradiotherapy response in recurrence patients with radical hysterectomy ,which is helpful for clinicians to predic treatment effect early .It has great significance for developing reasonable programs and impro-ving the therapeutic effect .
