Thrombolytic Therapy and Long Term Follow-up Study in a Child with Kawasaki Disease Complicated by Giant Coronary Aneurysm with Thrombosis.
- Author:
Su Jung MOON
;
Su Ya LEE
;
Kyong Hee NA
;
Sun Young PARK
;
Eun Young KIM
;
Kyoung Sim KIM
;
Yong Wook KIM
- Publication Type:Case Report
- Keywords:
Kawasaki disease;
Thrombosis;
Giant aneurysms;
Thrombolytic agents;
Coronary arteries;
Occlusion
- MeSH:
Aneurysm;
Arteries;
Aspirin;
Atherosclerosis;
Child*;
Coronary Aneurysm*;
Coronary Angiography;
Coronary Vessels;
Dipyridamole;
Fibrinolytic Agents;
Follow-Up Studies*;
Heart Ventricles;
Humans;
Infant;
Mucocutaneous Lymph Node Syndrome*;
Myocardial Ischemia;
Perfusion;
Thrombolytic Therapy*;
Thrombosis*;
Warfarin
- From:Journal of the Korean Pediatric Society
2003;46(3):302-307
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The long-term clinical issues in Kawasaki disease are concerned with the coronary artery lesions that result in aneurysmal formation, thrombotic occlusion, progression to ischemic heart disease, and premature atherosclerosis. We here report a 3 month old infant with Kawasaki disease complicated by giant coronary aneurysm with thrombosis. After urokinase(10,000 IU/kg) and heparin(400 IU/kg) were injected for two days as thrombolytic agents, thrombi were successfully dissolved. Even though long-term oral anticoagulation with low-dose aspirin, dipyridamole and coumadin were administered, thrombosis of the left main coronary artery was slowly increased. five years later, coronary angiography showed nearly total occlusion of the left anterior descending artery and collaterals from the right posterior branch and radionuclide scan demonstrated complete reversible perfusion defect of several portions of the left ventricle.
