Outcome of children with low- or intermediate-risk neuroblastoma：a report of 70 cases

VernacularTitle:儿童低中危神经母细胞瘤70例诊断和治疗分析
Author: Yanjing TANG ; Ci PAN ; Huiliang XUE ; Jing CHEN ; Lu DONG ; Min ZHOU ; Qidong YE ; Shuhong SHEN ; Yaoping WANG ; Longjun GU ; Jingyan TANG
Publication Type:Journal Article
Keywords: neuroblastoma; treatment; child
From: Journal of Clinical Pediatrics 2014;(5):413-416
CountryChina
Language:Chinese
Abstract: Objectives To evaluate the long-term outcomes of childhood low-or intermediate-risk neuroblastoma (NB) and their relevant prognostic factors. Methods A total of 70 new cases of low-or intermediate-risk NB diagnosed and treated by NB-99 protocol between 1999 and 2008 were analyzed retrospectively. Results Of these 70 NB patients, fourteen patients were in low-risk group and 56 were in intermediate-risk group. Sixty-seven patients reached complete remission (CR) or very good partial remission and 3 (5%) achieved partial remission. Ten patients relapsed. One patient occured second malignant neo-plasm. No patients died of chemotherapy-related adverse events or infections. The 5 year overall survival rate was 85.9%, event-free survival rate was 81.0%. Bone marrow infiltration, age at diagnosis, stage, lactate dehydrogenase level had a significant effect on prognosis. Conclusion Develop cytogenetic and molecular biology tests and pretreatment risk stratification are im-portant for further improvement of treatment protocol.