Outcome of children with low- or intermediate-risk neuroblastoma:a report of 70 cases
10.3969/j.issn.1000-3606.2014.05.004
- VernacularTitle:儿童低中危神经母细胞瘤70例诊断和治疗分析
- Author:
Yanjing TANG
;
Ci PAN
;
Huiliang XUE
;
Jing CHEN
;
Lu DONG
;
Min ZHOU
;
Qidong YE
;
Shuhong SHEN
;
Yaoping WANG
;
Longjun GU
;
Jingyan TANG
- Publication Type:Journal Article
- Keywords:
neuroblastoma;
treatment;
child
- From:
Journal of Clinical Pediatrics
2014;(5):413-416
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To evaluate the long-term outcomes of childhood low-or intermediate-risk neuroblastoma (NB) and their relevant prognostic factors. Methods A total of 70 new cases of low-or intermediate-risk NB diagnosed and treated by NB-99 protocol between 1999 and 2008 were analyzed retrospectively. Results Of these 70 NB patients, fourteen patients were in low-risk group and 56 were in intermediate-risk group. Sixty-seven patients reached complete remission (CR) or very good partial remission and 3 (5%) achieved partial remission. Ten patients relapsed. One patient occured second malignant neo-plasm. No patients died of chemotherapy-related adverse events or infections. The 5 year overall survival rate was 85.9%, event-free survival rate was 81.0%. Bone marrow infiltration, age at diagnosis, stage, lactate dehydrogenase level had a significant effect on prognosis. Conclusion Develop cytogenetic and molecular biology tests and pretreatment risk stratification are im-portant for further improvement of treatment protocol.