Clinical analysis of childhood hepatoblastoma

VernacularTitle:儿童肝母细胞瘤25例临床分析
Author: Weina HOU ; Xiang ZOU ; Jia GUO ; Lu WANG ; Guangyao SHENG ; Suke SUN
Publication Type:Journal Article
Keywords: hepatoblastoma; treatment; child
From: Journal of Clinical Pediatrics 2014;(5):417-420
CountryChina
Language:Chinese
Abstract: Objectives To investigate the rational treatment strategy of hepatoblastoma (HB) in children. Methods Clinical data and follow-up of 25 children with HB admitted from February 2009 to March 2013 were retrospectively analyzed. Results Twenty-five children with newly diagnosed HB (14 males and 11 females) were enrolled. The median age on diagnosis was 25 months (3-92 months);In 18 of 25 cases with complete resection of the primary tumor, 17 cases survived. Only 1 of 7 cases with incomplete resection survived. The survival rate in children with complete resection of primary tumor is significantly higher than those without complete resection (P<0.05). The survival rate in children of stage I or II is significantly higher than the children of stage III or IV (P<0.05). Conclusions Complete tumor resection is the cornerstone of therapy for long-term disease-free survival in HB patients. Treatment strategy remains to be further improved for children with recurrent and metastatic HB.