Influence of different dose dexmedetomidine on postoperative acute agitation and time to eyes opening in pediatric sevoflurane anesthesia
10.3760/cma.j.issn.1008-6706.2014.10.014
- VernacularTitle:不同剂量右美托咪啶对小儿七氟烷麻醉术后急性躁动及睁眼时间的影响
- Author:
Ying QIAN
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sevoflurane;
Anesthesia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(10):1472-1474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effective dose of dexmedetomidine on reducing agitation after sevoflurane anesthesia in patients undergoing repair of indirect inguinal hernia .Methods 105 patients ( ASAⅠ-Ⅱ) were randomly assigned into three groups ,35 cases in each group .In the observation group 1 and observation group 2, the patients received intravenous injection of dexmedetomidine 0.15μg/kg and 0.30μg/kg respectively.In the control group,the patients received intravenous injection of 0.9% normal saline solution 2mL before surgery.All patients were induced by 3%sevoflurane and maitained by 1.2%sevoflurane and hiatus sacralis block .During the operation, the BP,HR,SpO2,RR were recorded.At the end of anesthesia,the time to eyes opening (TEO) and agitation of emer-gence were recorded.Results The TEO of the control group,observation group 1,observation group 2 was (8.45 ± 4.02)min,(9.23 ±5.03)min,(10.81 ±4.06)min,respectively,and there were no significant differences among the three groups(all P>0.05).The incidence rate of agitation of the observation group 1 was 20.00%,which was signifi-cantly lower than that in the control group (42.86%) (χ2 =31.42,P<0.05 ),and that of the observation group 2(8.57%) was significantly lower than the control group and observation group 1(χ2 =24.37,7.53,all P<0.05). Conclusion The dose of dexmedetomidine 0.3μg/kg administered after induction of anesthesia can reduce the post-sevoflurane agitation in children and with no adverse effects .
