Preparation and Study of Acanthopanax Leaves Total Flavonoids Solid Dispersions In Vitro

VernacularTitle:刺五加叶总黄酮固体分散体的制备及其体外评价
Author: Linjian GAN ; Jing LIU ; Quanyi YU ; Caixia SUN ; Rongli YIN ; Jianchun SU ; Junxia ZHAO
Publication Type:Journal Article
Keywords: Acanthopanax leaves total flavonoids; carrier material; solid dispersion; dissolution
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(4):821-824
CountryChina
Language:Chinese
Abstract: This study was aimed to prepare solid dispersions of Acanthopanax leaves total flavonoids in order to im-prove its bioavailability. PEG4000, PEG6000, F68, PVPK30 were used as carrier materials in the preparation of four different types of solid dispersion to screen the best type of carrier material and evaluate the amount of carrier mate-rial and its influence on the drug dissolution. Rutin was used as reference substance. NaNO2-Al(NO3)3-NaOH was used as the color system, with a UV spectrophotometer measured absorbance at 500 nm. The dissolution characteris-tics of different proportions of solid dispersions were examined in vitro. The results showed that compared with raw material, the in vitro drug release rate with PVPK30 as carrier material in the obtained solid dispersion of the pro-portion of the raw material was significantly improved, and the cumulative release rate was also increased significant-ly. It was concluded that the solid dispersion prepared by solvent method significantly improved in vitro drug release in water.