Basic Knowledge and Research Progress on Cantharidin-based Molecules
10.11842/wst.2014.04.034
- VernacularTitle:斑蝥类化合物及其衍生物的基本概况和研究进展
- Author:
Hongfei DU
;
Yaobo ZENG
;
Yi ZHANG
;
Xiaoling LIU
- Publication Type:Journal Article
- Keywords:
Cantharidin;
norcantharidin;
Diels -Alder reaction;
phosphatase inhibitory activity;
structure modification
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(4):869-875
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to summarize main-bone structure of cantharidin-based small molecules and facts about three typical candidates including its origin, physical-chemical properties and general synthetic approaches. Basic chemical and pharmacological information as well as development of anti-cancer activities, which were related to cantharidin, norcantharidin and their analogues were reviewed, especially the relationship between the structures and their inhibitory activity and selectivity of serine-threonine protein phosphatases PP1, PP2A and PP2B in cancer treatment. The designs and developments of new biological cantharidin-based small molecules were also reviewed.