Basic Knowledge and Research Progress on Cantharidin-based Molecules

VernacularTitle:斑蝥类化合物及其衍生物的基本概况和研究进展
Author: Hongfei DU ; Yaobo ZENG ; Yi ZHANG ; Xiaoling LIU
Publication Type:Journal Article
Keywords: Cantharidin; norcantharidin; Diels -Alder reaction; phosphatase inhibitory activity; structure modification
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(4):869-875
CountryChina
Language:Chinese
Abstract: This study was aimed to summarize main-bone structure of cantharidin-based small molecules and facts about three typical candidates including its origin, physical-chemical properties and general synthetic approaches. Basic chemical and pharmacological information as well as development of anti-cancer activities, which were related to cantharidin, norcantharidin and their analogues were reviewed, especially the relationship between the structures and their inhibitory activity and selectivity of serine-threonine protein phosphatases PP1, PP2A and PP2B in cancer treatment. The designs and developments of new biological cantharidin-based small molecules were also reviewed.