Influence of Panax notoginseng saponins on COX-2,PGE-2 and PLA-2 in patients of acute exacerbation of chronic obstructive pulmonary disease with respiratory failure

VernacularTitle:三七总皂苷对慢性阻塞性肺疾病合并呼吸衰竭患者血清环氧化酶-2、前列腺素 E2和磷脂酶 A-2水平的影响
Author: Jiegen ZHANG ; Fulin DAI ; Fan WU
Publication Type:Journal Article
Keywords: Panax notoginseng saponins; Respiratory Insufficiency; Phospholipases A2
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(9):1286-1287
CountryChina
Language:Chinese
Abstract: Objective To investigate influence of Panax notoginseng saponins ( PNS) on Cyclooxygenase-2 (COX-2),Prostaglandin E2(PGE-2)and Phospholipases A2(PLA-2)in patients of acute exacerbation of chronic ob-structive pulmonary disease ( AECOPD) with respiratory failure .Methods One hundred AECOPD patients with re-spiratory failure were divided into the control group (n=50)and PNS group(n=50).The levels of blood serum COX-2,PGE-2 and PLA-2 of patients in the two groups were detected .Results The levels of blood serum COX-2,PGE-2 and PLA-2 of patients in PNS group were lower than those in control group ,the two groups after treatment significantly lower than those before treatment(P<0.05).Conclusion The levels of COX-2,PGE-2 and PLA-2 have influence on respiratory failure.PNS can reduce the COX-2,PGE-2 and PLA-2 concentrations in blood serum of patients ,mean-while it play a prominent role in inhibiting airway inflammatory and obstruction process .