Clinical study of gangliosides combined with hyperbaric oxygen therapy on neonatal ischemic encephalopathy

VernacularTitle:神经节苷脂联合高压氧治疗新生儿缺氧缺血脑病的临床研究
Author: Suxia HUANG
Publication Type:Journal Article
Keywords: Hypoxia,Brain; Combined Modality Therapy; Asphyxia Neonatorum
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(9):1340-1341
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effect of gangliosides combined with hyperbaric oxygen therapy( HBO) in treatment of neonatal ischemic encephalopathy ( HIE) .Methods 68 patients with HIE were ran-domly divided into 4 groups(n=17):the control group,gangliosides group,HBO group and combined group .The con-trol group received conventional therapy ,gangliosides and HBO group received gangliosides and HBO therapy respec-tively and combined group received both gangliosides and HBO therapy .The therapeutic effects were evaluated 10d and 20d after treatment.Results Compared with the control group ,the total efficiency was significantly increased in the combined group(χ2 =5.885,P<0.05),but not in gangliosides and HBO group .Moreover,all treatment groups significantly elevated the neonatal behavioral neurological assessment (NBNA)in day 10 and 20,and there were signif-icant differences between the combined group and gangliosides or HBO group ( t=3.755,P<0.05;t=3.533,P<0.05).Conclusion The use of gangliosides combined with HBO has synergistic interaction in treatment of HIE , which is worthy of clinical application .