Progress on the relationship between Foxp3 and malignant tumor treatment
10.3969/j.issn.1000-8179.20121656
- VernacularTitle:Foxp3与恶性肿瘤治疗关系的研究进展
- Author:
Qiang XUE
;
Jihui HUI
- Publication Type:Journal Article
- Keywords:
Foxp3;
Regulatory T cells;
malignant tumor;
therapy
- From:
Chinese Journal of Clinical Oncology
2014;(9):608-610
- CountryChina
- Language:Chinese
-
Abstract:
The expression of transcription factor forkhead box protein 3 (Foxp3) is predominantly restricted to the CD25+CD4+population in both the thymus and periphery. Limited evidence indicated that Foxp3 is also expressed, albeit to a lesser extent, in the tis-sues outside of the thymus and spleen. However, recent studies showed that Foxp3 is expressed in many tumor cells, and has a definite relation with the occurrence, progress, and prognosis of malignant tumors. Foxp3 has become a popular topic in research on malignant tumor treatment, thereby bringing a new turning point for malignant tumor therapy.
