Expression and prognostic value of ING4 and HIF-1α in rectal cancer tissue
10.3969/j.issn.1006-5725.2014.03.016
- VernacularTitle:生长抑制因子4和缺氧诱导因子-1α在直肠癌组织中的表达及其与预后的关系
- Author:
Haizhou ZHAO
;
Yueping NIU
;
Xiaoyi REN
;
Yingfa ZHOU
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
ING4;
HIF-1α;
Immunohistoehemistry;
Prognosis
- From:
The Journal of Practical Medicine
2014;(3):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibitor of growth family member 4 (ING4) and hypoxia inducible factor-1α(HIF-1α)expression in colorectal cancer and the prognostic significance. Methods Immunohistochemistry was used to detect the ING4 and HIF-1α expression in 133 cases of colorectal cancer tissues and 76 cases of normal rectal tissues. Survival analysis was performed on the following data. Results ING4 in colorectal cancer tissues with positive rate (53.4%) was significantly lower than normal rectal tissue (85.5%) and the difference was statistically significant (P < 0.01); HIF-1α in colorectal cancer tissues with positive rate (69.9%) is higher than normal rectal tissue (42.1%), and the difference was statistically significant (P < 0.01); ING4 and HIF-1αexpression was related with tumor differentiation, Dukes stage and lymph node metastasis (P < 0.05); colorectal cancer tissues ING4 and HIF-1α expression was negatively correlated (r = -0.317, P < 0.001); By multivariate analysis, tumor differentiation, Dukes stage, lymph node metastasis, ING4 expression of HIF-1α expression has independent prognostic significance. Conclusion ING4 and HIF-1α may be involved in the occurrence and development of colorectal cancer , and combined detection could help determine the prognosis of colorectal cancer.
