Effect on Liver and Kidney of Mice by Traditional Chinese Medicine Compatibility of Paeoniae Radix Rubra and Veratrum Nigrum
10.3969/j.issn.1005-5304.2014.05.015
- VernacularTitle:赤芍与藜芦配伍对小鼠肝脏及肾脏损伤的影响
- Author:
Ning YAO
- Publication Type:Journal Article
- Keywords:
Paeoniae radix rubra;
Veratrum nigrum;
eighteen incompatible medicaments;
liver;
kidney;
oxidation-antioxidation balance;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(5):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the damage of mice liver and kidney with the compatibility application of Paeoniae radix rubra and Veratrum nigrum, and explore its mechanism. Methods We examined the alanine aminotransferase, aspartate aminotransferase (AST), lactic dehydrogenase, creatinine and urea nitrogen from serum, and glutathion peroxidase (GSH-Px) and malondialdehyde (MDA) from liver and kidney tissue after intragastric administration of different ratio (4∶1, 2∶1, 1∶1, 1∶2, 1∶4) of Paeoniae radix rubra and Veratrum nigrum in mice for 22 d. Results Paeoniae radix rubra used with Veratrum nigrum did not induce the obvious damage to liver with AST increase, but induced the obvious damage to kidney. At the same time, the depressed GSH-Px activity and the increased MDA content were observed in kidney tissue. When Paeoniae radix rubra and Veratrum nigrum is on a ratio of 2∶1, the kidney injury was the most obvious. Conclusion Paeoniae radix rubra used with Veratrum nigrum in varying proportions could induce the kidney injury in mice which is related to the oxidation-antioxidation balance disturbance.
