Determination of Residual Organic Solvents in Paclitaxel by Capillary GC
- VernacularTitle:毛细管柱气相色谱法测定紫杉醇中4种残留溶剂
- Author:
Yongjun LOU
- Publication Type:Journal Article
- Keywords:
Capillary GC;
Headspace injection;
Residual organic solvents
- From:
China Pharmacist
2014;(4):588-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a capillary GC method for the determination of residual organic solvents in paclitaxel. Meth-ods:The standard solution and test solution was respectively injected into an HP-INNOWAX sillica capillary column by headspace in-jection. The chromatograms were recorded with an FID. The injection port and detector temperature was 250℃ and 300℃, respective-ly, the initial column temperature was kept at 35℃ for 5 min, and then was risen to 260℃ at the rate of 25℃/min. Results:The four residual organic solvents could be separated completely. The resolution and sensitivity were acceptable. Conclusion: The method is proved to be simple, rapid, sensitive and reliable, and can be used in the determination of residual organic solvents in paclitaxel.
