Clinical observation of tegafur pins cisplatin combined with three-dimensional conformal radiotherapy in the treatment of non-operation esophageal carcinoma
10.3760/cma.j.issn.1006-9801.2014.03.006
- VernacularTitle:替加氟加顺铂联合三维适形放疗治疗非手术食管癌临床观察
- Author:
Danxia LIN
;
Shijian CHEN
;
Chen CHEN
;
Xihui QIU
;
Meimei FANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Three-dimensional conformal radiotherapy;
Chemotherapy;
Radiochemotherapy;
Therapeutic effect observation
- From:
Cancer Research and Clinic
2014;26(3):163-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effetive,toxicity and survial rate of non-operation esophageal carcinoma patients treated by tegafur plus cisplatin combined with three-dimensional conformal radiotherapy (3D-CRT).Methods 184 cases of non-operation patients with esophageal carcinoma were divided into two groups.The cases of treatment group were treated by cisplatin and tegafur.The cases of control group were treated by cisplatin and 5-Fu.All patients received 3D-CRT,and the total radiation dose was 50-70 Gy.Each group had 14 cases treated with primary chemotherapy for 1 course,28 cases for 2 courses,and 50 cases without any chemotherapy.Results The recent effect rate was 69.57 % (64/92) in treatment group and 67.39 % (62/92) in control group,there was no statistical difference (x2 =0.101,P =0.874).Radioactive esophagitis and leukopenia were the main side effect of treatment.The treatment group was significantly lower than that of the control group,the difference had statistical significance.The 1-,2-and 3-year survival rates were 74.9 %,61.6 %,52.8 %,respectively in treatment group and 75.8 %,56.9 %,48.0 %,respectively in control group.The control group survival rates were significantly higher than the treatment group,the difference had statistical significance (x2 =7.325,P =0.007).Conclusions Cisplatin plus tegafur or 5-Fu combined with 3D-CRT is effective way of treatment for non-operation of esophageal carcinoma.The toxicity of cisplatin plus tegafur group is significantly lower than cisplatin plus 5-Fu group,therefor it can improve the quality of life of the patients obviously.