Research progress of microRNA in lung cancer
10.3760/cma.j.issn.1006-9801.2014.02.018
- VernacularTitle:微小RNA在肺癌中的研究进展
- Author:
Jin LYU
;
Xiujun SONG
- Publication Type:Journal Article
- Keywords:
Lung neoplsms;
microRNA;
Biomarkers
- From:
Cancer Research and Clinic
2014;26(2):129-133
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a group of multifunctional regulators which plays crucial role in physiological and pathological processed ranging from development,differentiation and apoptosis to stress responscs.Over 50 ％ miRNAs are located in the tumor-associated region or the fragile chrosomal regions which are susceptible to amplification,deletion or translocation during the process of tumor onset and development.More recently,the new publications indicated that the miRNAs broaden the insight for the mechanism research of tumor metastasis and the applications of miRNAs in carcinoma diagnosis.The article focuses on the mechanism by which some miRNAs are deregulated in lung cancer,the clinical potential of these molecules as the diagnosis and prognosis biomarkers and the future of miRNAs to be potential therapeutic drugs.
