Research progress of relationship between myelodysplastic syndromes and iron overload
10.3760/cma.j.issn.1006-9801.2014.03.022
- VernacularTitle:骨髓增生异常综合征与铁过载关系的研究进展
- Author:
Na SONG
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Transfusion dependence;
Iron overload
- From:
Cancer Research and Clinic
2014;26(3):209-211
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes (MDS) is a highly heterogeneous group of clonal disease,which is derived from hematopoietic.stem cells.Anemia is the main manifestation of most MDS patients and transfusion is required in about 90 ％ patients.Long-term blood transfusions can lead to iron overload (IOL).IOL can damage the iron balance,and excess free iron can deposite in the heart,liver and other vital organs,resulting in structural damage and organ dysfunction,which can deteriorate the prognosis,accelerate the transformation into acute myeloid leukemia,and increase the mortality.Iron chelation can improve the prognosis of patients with IOL,and prolong the overall survival and leukemia-free survival.
