Expressions and clinical significance of Nanog and CD44 protein in lung cancer
10.3969/j.issn.1006-5725.2014.04.019
- VernacularTitle:Nanog和CD44蛋白在肺癌中的表达及其临床意义
- Author:
Biwen MO
;
Laodong LI
;
Changming WANG
;
Jinrong ZENG
;
Jiying WANG
;
Jianghong WEI
;
Feng CHEN
;
Jianwei HUANG
;
Huina YU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Nanog;
CD44;
Diagnostic marker;
Therapeutic target
- From:
The Journal of Practical Medicine
2014;(4):560-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions and clinical significance of Nanog and CD44 protein in lung cancer. Methods The expressions of Nanog and CD44 were detected by immunohistochemistry in 50 cases of lung cancer, 32 cases of benign lesion lung tissue and 18 cases of paraneoplastic normal lung tissue. Then their relationships with clinicopathological factors were analyzed. Results The expression of Nanog in lung cancer was significantly higher than those in benign lesion lung tissue and paraneoplastic normal lung tissue (P < 0.05). There was no significant difference of the expression of CD44 among the three groups (P > 0.05). The expressions of Nanog and CD44 in squamous cell carcinomas were higher than those in adenocarcinomas and small cell lung carcinomas (P < 0.05). The expressions of Nanog and CD44 were significantly correlated with lymph node metastasis (P < 0.05), but were not correlated with age, gender, tumour size, TNM stage and differentiation of lung cancer (P>0.05). The positive correlation was also noted between the expressions of Nanog and CD44 in lung cancer (r = 0.564, P < 0.05). Conclusion Nanog and CD44 proteins may participate in the genesis and progression of lung cancer. Nanog protein is a potential diagnostic marker and therapeutic target for lung cancer.
