Relationship between the serum levels of soluble vascular adhesion protein-1 And transaminase、hyaluronic acid in patients with chronic hepatitis C
10.3969/j.issn.1006-5725.2014.04.024
- VernacularTitle:慢性丙型肝炎患者血清可溶性血管黏附蛋白-1含量与转氨酶、透明质酸水平的相关性分析
- Author:
Lisha PENG
;
Qingfeng ZHU
;
Guanghai CHEN
;
Weize ZUO
- Publication Type:Journal Article
- Keywords:
Hepatitis C;
vascular adhesive protein;
Hyaluronic acid;
Soluble
- From:
The Journal of Practical Medicine
2014;(4):574-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of serum levels of soluble vascular adhesion protein (sVAP-1), hyaluronic acid (HA) in chronic hepatitis C (CHC) patients, to analysis the relationships between serum sVAP-1 and liver function、HA ,to explore the role of sVAP-1 on the pathogenesis of CHC. Method In our research, 88 cases CHC patients were divided into 2 groups,30 cases serum HCV RNA negative (CHC1 gruop)、58 cases serum HCV RNA opsitive (CHC2 gruop);30 cases healthy individuals were enrolled in our research;the serum levels of sVAP-1 and HA were determined by ELISA; Liver function was assayed by automatic biochemistry analyzer;HCV RNA load was measured by real-time polymerase chain reaction (PCR). Results In CHC1,CHC2 and healthy control groups,serum level of sVAP-1 were (112.75 ± 39.00),(154.24 ± 45.88)and (72.23 ± 35.82) ng/mL(F=38.76,P<0.01),respectively; serum level of HA were(87.03 ± 24.95),(132.98 ± 33.54)and (75.07 ± 24.09)ng/mL,respectively (F=47.44,P<0.01);The concentrations of serum sVAP-1、 HA gradually had been increasing with level of ALT (all P<0.05);Especially,significantly positive associations were highly between serum sVAP-1 and ALT 、AST and HA (r=0.711、0.628、0.816, all P<0.001). Conclusion Serum sVAP-1 may be closely related to the hepatic cell inflammatory injury and liver fibrosis in CHC patients.
