The value of serum HMGB1 and CA72-4 in patients with early gastric cancer
10.3760/cma.j.issn.1008-6706.2014.07.024
- VernacularTitle:血清高迁移率族蛋白 B1和糖类抗原72-4在早期胃癌患者检测中的价值
- Author:
Xinfang ZHANG
;
Ying HU
- Publication Type:Journal Article
- Keywords:
Highmobility group box-1;
Carbohydrate antigen 72-4;
Stomach neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(7):1014-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of serum HMGB1(high mobility group box-1) and carbohydrate antigen 72-4(CA72-4) in patients with early gastric cancer .Methods 50 cases of early gastric cancer patients were enrolled as a group ,45 cases of gastric lesions as benign gastric benign group ,100 cases of healthy people as healthy group.Serum HMGB1 and CA72-4 in all people were detected .Results Early gastric cancer serum HMGB1 and CA72-4 was higher than benign lesions in the stomach and the healthy group (χ2 =33.69,82.95,51.41,104.74, P<0.01),while benign lesions of the stomach and the positive rate healthy group ,the difference was not statistically significant(χ2 =3.80,1.90,all P>0.05).HMGB1 diagnosis of early gastric cancer sensitivity was 70.0%,specific-ity 95.2%and accuracy was 88.7%.CA72-4 diagnosis of early gastric cancer with a sensitivity of 80.0%(40/50), specificity was 97.2%(141/145) an accuracy of 92.8%(181/195).Joint detection,diagnosis of early gastric cancer with a sensitivity of 94.0%(47/50),while the specificity was 93.1%(135/145),the accuracy was 93.3%(182/195),higher than those of the single detection sensitivity and accuracy .Early gastric cancer with lymph node metasta-sis in patients with serum HMGB1 and CA72-4 were significantly higher than those in patients without lymph node metastasis,the two groups were significantly different (t=2.927,4.096,all P<0.05).Conclusion Joint detection of serum HMGB1 and CA72-4 allows early diagnosis of gastric cancer ,and to determine the prognosis of patients .
