Obesity as a Risk Factor for Prostatic Enlargement: A Retrospective Cohort Study in Korea.
- Author:
Jae Hung JUNG
1
;
Song Vogue AHN
;
Jae Mann SONG
;
Se Jin CHANG
;
Kwang Jin KIM
;
Sung Won KWON
;
Sang Yoo PARK
;
Sang Baek KOH
Author Information
- Publication Type:Original Article
- Keywords: Adiponectin; Leptin; Obesity; Prostatic Hyperplasia
- MeSH: Adiponectin; Adipose Tissue; Atherosclerosis; Body Mass Index; Cohort Studies*; Epidemiology; Genome; Humans; Intra-Abdominal Fat; Korea*; Leptin; Male; Mass Screening; Obesity*; Obesity, Abdominal; Prostate; Prostate-Specific Antigen; Prostatic Diseases; Prostatic Hyperplasia; Retrospective Studies*; Risk Factors*; Testosterone; Ultrasonography; Waist Circumference
- From:International Neurourology Journal 2016;20(4):321-328
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. METHODS: Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure. RESULTS: Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95% confidence interval [CI], 1.088–1.336), waist circumference (OR, 1.073; 95% CI, 1.032–1.115), body fat (OR, 1.126; 95% CI, 1.056–1.202), and visceral fat composition (OR, 1.667; 95% CI, 1.246–2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95% CI, 1.103–11.365) and adiponectin levels (OR, 0.315; 95% CI, 0.102–0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels. CONCLUSIONS: Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.
