The optimal power of experimental endoscopic ultrasonography-guided pancreas radiofrequency ablation therapy

VernacularTitle:内镜超声引导下胰腺射频消融治疗最佳功率的实验研究
Author: Wei XU ; Yan LIU ; Peng PAN ; Yan GUO ; Zhaoshen LI
Publication Type:Journal Article
Keywords: Pancreas; Endoscopic ultrasonography; Radiofrequency ablation; Optimal power
From: Chinese Journal of Digestive Endoscopy 2014;31(3):152-154
CountryChina
Language:Chinese
Abstract: Objective To explore the optimal power of experimental pancreatic endoscopic ultrasonography (EUS)-guided radiofrequency ablation (RFA) therapy.Methods Six healthy live minipigs were randomly divided into two groups according to random number table,which received RFA under EUS or in laparotomy.Each pig in each group was randomly allocated to received RFA at different power (5 W,10 W,15 W).The impedance was monitored and the time for each therapy was recorded.The width diameter of coagulation necrosis from RFA was measured by EUS and gross pathology.Results RFA was completed in all pigs smoothly with stable life signs and without complications.Gross and micro pathologic observation confirmed formation of coagulation necrosis lesions.The width diameter of lesions from EUS-RFA was similar to that from surgery RFA,both having a maximum value at 10 W power (11 nun VS 10 mm).Conclusion The optimal power of experimental pancreatic EUS-RFA in pig is 10W,which should be further explored for the clinical purpose.