Cognition is correlated with auditory event-related potential P300 after traumatic brain injury
10.3760/cma.j.issn.0254-1424.2014.03.003
- VernacularTitle:脑外伤患者P300与认知功能的相关性研究
- Author:
Minghua ZHONG
;
Peiyuan LI
;
Qixiu ZHU
;
Yunxia LIU
- Publication Type:Journal Article
- Keywords:
Traumatic brain injury;
Cognitive dysfunction;
Event-related potentials;
P300;
Montreal cognitive assessment
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2014;36(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate any correlation between cognition and auditory event-related potential (ERP) after traumatic brain injury (TBI),and to explore the diagnostic value of the P300 ERP for TBI patients.Methods Thirty TBI patients and 28 healthy subjects were recruited.Their P300 auditory event-related potentials were measured and the Montreal cognitive assessment (MoCA) was administered.Results The TBI patients' total MoCA scores and their scores on most of the sub-item components were significantly lower than those of the control subjects,though their naming and speech showed no significant difference.The TBI patients had abnormal P300 responses.Their N1,P2,N2 and P3 latencies were significantly longer and their P2 and P3 amplitudes were significantly lower than those of the control group.Stepwise regression and multivariate analysis showed that the P300 latency was significantly associated with delayed memory,impaired visual spatial executive functioning and total MoCA score.Conclusion P300 can be used as a quantitative electrophysiological index for detecting cognitive impairment in patients with TBI.
