Clinical analysis of seven cases of generalized pustular psoriasis of pregnancy
10.3760/cma.j.issn.1007-9408.2014.04.009
- VernacularTitle:妊娠期泛发性脓疱型银屑病7例临床分析
- Author:
Xianlan ZHAO
;
Yingying DU
;
Jianbin YU
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Psoriasis;
Pregnancy outcome
- From:
Chinese Journal of Perinatal Medicine
2014;17(4):249-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics,diagnosis,therapy and maternal and perinatal prognosis of generalized pustular psoriasis of pregnancy.Methods Clinical data for seven inpatients with generalized pustular psoriasis of pregnancy were retrospectively analyzed from January 1,2005 to December 31,2012.Results Three patients had family history of psoriasis and five had previous history of psoriasis.All skin lesions were large patches of erythema,with needlepoint to miliary size pustules and scales.Two patients had oral involvement and three had nail involvement.Biopsy and bacterial culture were performed on five patients,in whom histopathological changes of pustular psoriasis were found,and bacterial culture was negative except in one patient.Among the patients,four had confirmed cause of disease; six patients were complicated with fever; four had increased leukocytes; seven had elevated neutrophils and C-reactive protein;five had increased total protein; and six had increased albumin.The disease was diagnosed according to the clinical manifestations and laboratory tests.Comprehensive treatment with glucocorticosteroids,antibiotics and local treatment were performed.Four patients had live births,and three patients underwent odinopoeia.Two babies were healthy,one had died,and another had varus foot deformity.Three patients had pustular relapse after labor.Conclusions Fetal-placental functions of patients with generalized pustular psoriasis of pregnancy should be monitored closely.Early diagnosis,treatment and termination of pregnancy can improve the maternal and perinatal prognosis.
