Clinical analyses of 2 preoperative chemotherapies for Ⅰb2-Ⅱb cervical cancer

VernacularTitle:宫颈鳞癌术前两种化疗方法临床效果分析
Author: Kunling SONG ; Yao YANG ; Ping HOU
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Antineoplastic combined chemotherapy protocol
From: Chinese Journal of General Practitioners 2014;13(4):295-297
CountryChina
Language:Chinese
Abstract: A total of 104 patients with cervical squamous cell cancer (Figo Ⅰ b2-Ⅱ b) were recruited during March 2006 and October 2011.One group (A,n =50) received preoperative intravenous neoadjuvant chemotherapy while another group (B,n =54) had interventional arterial chemotherapy plus bilateral uterine artery embolization.Surgery was performed for those with a change of cancer size either as complete or partial remission at Week 2 post-chemotherapy according to the WHO evaluation criteria.Otherwise radiotherapy was implemented.The ratio of surgery after chemotherapy was 70％ (n =35) in Group A versus 87％ (n =47) in Group B (P ＜ 0.05).For Group A,there were blood vessel invasion (n =6,17％),lymph node metastasis (n =8,23％) and positive margin (n =1,3％).For Group B,(n =7,15％),(n =9,21％) and (n =1,2％).There was no significant inter-group statistic difference (P ＞ 0.05).Preoperative chemotherapy is effective for cervical squamous cancer (tumor diameter ＞ 4 cm)with fewer side effects.