Clinical analyses of hematological abnormalities in systemic lupus erythematosus

VernacularTitle:系统性红斑狼疮血液学异常的临床分析
Author: Wengen LI ; Jingye LIAO ; Chunmei HE ; Ke ZHANG ; Xuechun HE
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Hematology
From: Chinese Journal of General Practitioners 2014;13(4):305-307
CountryChina
Language:Chinese
Abstract: To explore the characteristics of hematological abnormalities in patients with systemic lupus erythematosus (SLE) through retrospective analysis.A total of 445 SLE patients were recruited and divided into 5 groups of low white blood cell,immune thrombopenic purpura,anemia,pancytopenia and control without hematological abnormalities.Among them,351 (78.9％) had hematological abnormalities and 94 (21.1％) without hematological abnormities.The prevalence of anemia,leucocytopenia,thrombocytopenia and pancytopenia were 56.0％ (246/445),27.6％ (123/445),13.5％ (60/445) and 8.5％ (38/445) respectively.The incidence of renal damage in anemia group was significantly higher than that in control group (P ＜ 0.01).SLE patients with hematological abnormalities had lower complement C3 levels (P ＜ 0.05) and higher systemic lupus erythematosus disease activity index (SLEDAI) (P ＜ 0.01).Anemia is the most common findings in SLE patients with hematological abnormalities who have lower complement C3 levels and higher SLEDAI.