Incidence and risk factors of post-transplant diabetes mellitus in heart recipients
10.3760/cma.j.issn.0254-1785.2014.04.007
- VernacularTitle:心脏移植受者移植后新发糖尿病的危险因素分析
- Author:
Baoyong ZHANG
;
Shengshou HU
;
Jie HUANG
;
Yunhu SONG
;
Wei WANG
;
Zhongkai LIAO
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
Diabetes mellitus;
Risk factors;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2014;35(4):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the incidence and independent risk factors of new onset posttransplantation diabetes mellitus (PTDM) and its prognostic value in medium term survival rate in heart transplant recipients.Method We performed a retrospective study on all heart transplant recipients in a single center from June 2004 to May 2012,and selected 226 patients without DM in pretransplant period with median 41-month follow-up.According to the diagnostic criteria of the American Diabetes Association (ADA) 2006 revised edition of PTDM,the selected patients were divided into PTDM (group 1) and NPTDM (group 2).Univariate analysis and logistic regression analysis were used to determine preoperative and postoperative risk factors responsible for PTDM.Kaplan-Meier method and Log rank test were used for survival analysis.Result Of the 226 patients,53 case developed DM (23.5 ％).The multivariate analysis identified the following as predictive factors for the development of PTDM:age ([OR]:1.05,95％ CI:1.01 ～2.30,P =0.012),and first-degree relatives of family history of DM ([OR]:1.90,95％ CI:1.04～4.10,P =0.032).The 1-,3-and 5-year survival rate in PTDM patients post-transplantation was 100.0％,98.0％ and 89.8％,and that in NPTDM patients was 98.2％,94.2％ and 92.4％,respectively.Log Rank test displayed no significant difference between two survival curves (P＞0.05).Conclusion PTDM is a frequent comorbidity after HT.Age and first-degree relatives of family history of DM were significant and independent risk factors for the development of PTDM during the follow-up period.By appropriate treatment,the medium-term survival rate of patients with PTDM was unaffected.
