Meta-analysis on the two medications to prevent cytomegalovirus infection in recipients of renal transplants
10.3760/cma.j.issn.0254-1785.2014.04.006
- VernacularTitle:肾移植后巨细胞病毒感染的先驱治疗和普遍预防方案的荟萃分析
- Author:
Lanlan CHEN
;
Anping NI
;
Jingtao CUI
;
Wenjuan YAN
;
Lingjun KONG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Cytomegalovirus;
Preemptive;
Prophylaxis;
Meta-analysis
- From:
Chinese Journal of Organ Transplantation
2014;35(4):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of the two antiviral medications in preventing cytomegalovirus infection and cytomegalovirus disease in renal transplant recipients.Method We searched articles from Pubmed,EMbase,Cochrane Library,Wanfang Med Online,and China's biomedical journal citation database on line.Randomized controlled trials evaluating preemptive treatment and universal prophylaxis for cytomegalovirus infection and cytomegalovirus disease in renal transplant recipients were reviewed.Two reviewers screened studies and assessed study quality according to the study population,intervention measure and results.Finally data from included studies were subjected to meta-analysis.Result Six studies involving total 752 renal transplant recipients were included in this review.Compared with preemptive treatment,universal prophylaxis significantly reduced the risk of cytomegalovirus infection at 3 rd and 12 th month,and the risk of cytomegalovirus disease at 12 th month after transplantation (RR =12.13,95 ％ CI.6.59～22.36,P＜0.05; RR =2.21,95％CI:1.62～3.01,P＜0.05; RR=1.79,95％Chl.22～2.63,P＜0.05).There was no statistically significant difference in the incidence of other opportunistic infection and acute rejection.Conclusion Universal prophylaxis was more effective than preemptive treatment in preventing CMV infection and CMV disease in renal transplant recipients.
