A case of S100-positive atypical juvenile xanthogranuloma: a longitudinal observation and review of the literature
10.3760/cma.j.issn.0412-4030.2014.04.006
- VernacularTitle:S100阳性不典型幼年性黄色肉芽肿一例随访观察并文献复习
- Author:
Yanhong WANG
;
Hong SHEN
;
Aie XU
- Publication Type:Journal Article
- Keywords:
Xanthogranuloma,juvenile;
S100 proteins;
Antigens,CD1
- From:
Chinese Journal of Dermatology
2014;47(4):247-250
- CountryChina
- Language:Chinese
-
Abstract:
A 3-year-old boy presented with a 3-month history of brown-yellow papules scattered on the trunk.The first skin biopsy showed a dermal infiltrate of many mononuclear histiocytes,eosinophilic granulocytes and a small number of lymphocytes.Immunohistochemical examination of the lesions demonstrated positive reactions with anti-CD68,-S100 and-CD1a (partial) antibodies.After the biopsy,the skin lesions gradually turned dark and partially regressed leaving hyperpigmentation,but new lesions continuously appeared.Four months later,a second biopsy was performed,and showed a dermal infiltrate of histiocytes with eosinophilic granulocytes and a few multinucleated giant cells.Immunohistochemistry showed that the histiocytes stained positive for CD68,but negative for S100 and CD1a.Based on the above findings,the patient was diagnosed with juvenile xanthogranuloma.
