The prevalence and clinical significance of arthritis in patients with systemic sclerosis
10.3760/cma.j.issn.0578-1426.2014.06.012
- VernacularTitle:系统性硬化病合并关节炎的临床分析
- Author:
Chanyuan WU
;
Qian WANG
;
Dong XU
;
Mengtao LI
;
Yong HOU
;
Xiaofeng ZENG
- Publication Type:Journal Article
- Keywords:
Scleroderma,systemic;
Arthritis;
Lung diseases,intestinal
- From:
Chinese Journal of Internal Medicine
2014;53(6):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prevalence and independent influencing factors of arthritis in Chinese patients with systemic sclerosis(SSc).Methods A total of 248 SSc patients were enrolled in this prospective cross-sectional study in Peking Union Medical College Hospital.Demographic,clinical and laboratory data were compared in arthritis group and non-arthritis group.Results Of 248 Chinese SSc patients,mean age of onset was (37.1 ± 13.7) years old and disease duration was (7.4 ± 5.2) years.Overall prevalence of arthritis was 41.1％ (102/248).The presence of arthralgia(95.1％ vs 15.1％),muscle weakness(38.2％ vs 24.7％),short of breath (60.8％ vs 45.2％),and intestinal lung disease (64.7％ vs 49.3％) occurred more frequently in patients with arthritis than those without arthritis (P ＜0.05).The elevation of C reactive protein,anti-Sm and anti-cyclic citrullinated peptide were more common in arthritis group than in non-arthritis group(61.4％ vs 43.9％,11.4％ vs 2.5％ and 28.1％ vs 2/16,respectively).There were no obvious differences in the Rodnan score,digital ulcers,pulmonary arterial hypertension,and six-minute walk test between two groups(P ＞ 0.05).Conclusion This study reveals the significant prevalence of arthritis in a large cohort of SSc patients in China.Compared to non-arthritis patients,the SSc patients with arthritis have a more severe inflammation reaction and a higher rate of intestinal lung disease.
