Early postnatal overnutrition results in insulin resistance in adulthood
10.3760/cma.j.issn.1000-6699.2014.05.002
- VernacularTitle:出生后早期营养过度导致成年期胰岛素抵抗
- Author:
Fei BEI
;
Wei CAI
- Publication Type:Journal Article
- Keywords:
Postnatal;
Overnutrition;
Insulin resistance;
Metabolic syndrome
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(5):368-372
- CountryChina
- Language:Chinese
-
Abstract:
Overnutrition during the early postnatal life,a critical time window for growth and development,may induce metabolic syndrome later in life,including overweight/obesity and insulin resistance.The important target organs of insulin,such as liver,adipose tissue,skeletal muscle,and central nervous systems show insulin resistance.The involved mechanisms include abnormality of insulin signal pathway,increment of free fatty acid and some adipocytokines,oxidative stress,maladjustment of orexigenic and anorexigenic neuron,modifications of the hypothalamic-pituitary-adrenal glucocorticoid axis as well as epigenetic,etc.Hence,overnutrition should be avoided during the early postnatal life,so as to decrease the risk of developing long-term insulin resistance.
