Correlation between immune regulation and miRNAs in type 1 diabetes
10.3760/cma.j.issn.1000-6699.2014.05.020
- VernacularTitle:1型糖尿病中miRNA与免疫调控的相关性及其研究进展
- Author:
Guofeng WANG
;
Tao YANG
- Publication Type:Journal Article
- Keywords:
microRNA;
Diabetes mellitus,type 1;
Autoimmune diseases
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(5):441-443
- CountryChina
- Language:Chinese
-
Abstract:
It is well established that type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease.Controversial data exist regarding the differential control of the immune system in TI DM.Recent studies have demonstrated that MicroRNAs (miRNAs),single-stranded noncoding RNAs,may play a key role in regulation of gene expression in the immune system.Dicer enzymes or abnormal miRNAs may lead to autoimmune reactions,and thus is expected to become a target for early diagnosis and treatment of T1DM in the future.This article reviews the correlations of known miRNAs with the immune regulation in T1DM and the research progression.
