Effect of liraglutide on catch-up fat in high-fat diet-induced catch-up growth rat model
10.3760/cma.j.issn.1000-6699.2014.05.014
- VernacularTitle:利拉鲁肽早期干预对高脂饮食追赶生长大鼠脂肪追赶生长的作用
- Author:
Ting CHEN
;
Lulu CHEN
;
Juan ZHENG
;
Ying ZHU
;
Jiaoyue ZHANG
- Publication Type:Journal Article
- Keywords:
Catch-up growth;
High-fat diet;
Glucagon-like peptide-1;
Catch-up fat
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(5):417-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether liraglutide treatment can prevent catch-up fat in high-fat dietinduced catch-up growth rats,and to discuss the possible underlying mechanisms.Methods Sixty-four SpragueDawley rats were stratified into 4 groups:normal control group,catch-up growth (CUG) group,catch-up growth with liraglutide treatment (CUGL) group,and catch-up growth with liraglutide plus exendin (9-39) treatment (CUGLE) group.All the catch-up growth animals underwent a4 week high-fat diet re-feeding phase after a4 week food restriction phase.Body weight and food intake were measured every day.At the end of food restriction and re-feeding,body composition was measured via Dual energy X-ray absorptiometry.After the rats were sacrificed,body fat distribution and plasma lipid levels were determined.Results By the end of catch-up growth,body weight,energy intake,Lee' s index,fat body mass,visceral adipose tissue/body weight,subcutaneous adipose tissue/body weight,triglyceride,free fatty acid,low density lipoprotein-cholesterol levels were lower in CUGL rats compared with CUG rats (all P＜0.01).There were no significant differences in energy intake,body composition,fat body mass,and blood lipid levels between CUGLE rats and CUG rats,while the weight of CUGLE rats was significantly lower than CUG ones.Conclusions Liraglutide infusion protects rats with high-fat diet induced catch-up growth from catch-up fat mainly via a glucagon-like peptide-1 receptor dependent manner.
