Association between the level of serum vitamin D and peripheral neuropathy in type 2 diabetic patients

VernacularTitle:血清维生素D水平与2型糖尿病周围神经病变的关系
Author: Jiping ZHANG ; Ning XU ; Dong YIN ; Yuan HUI ; Ning MA ; Guanjun HAN ; Jing LIU
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Diabetic peripheral neuropathy; Vitamin D
From: Chinese Journal of Endocrinology and Metabolism 2014;30(5):385-387
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between 25-(OH) vitamin D [25-(OH) D] level and peripheral neuropathy in patients with type 2 diabetes mellitus.Methods Eighty patients with type 2 diabetes mellitus were enrolled in this cross-sectional study,including 37 subjects with and 43 without diabetic neuropathy.Anthropometric data was collected and serum levels of 25-(OH) D,HbA1c,blood lipid,and hepatic and renal functions were determined in all patients.Results Serum 25-(OH) D level was significantly lower in patients with diabetic neuropathy compared to those without neuropathy [(12.73 ± 4.68 vs 17.56 ± 5.28) ng/ml,P＜0.01].Logistic regressions demonstrated that vitamin D level was associated with diabetic neuropathy (OR=1.222,95％ CI 1.095-1.364).Conclusions Vitamin D insufficiency is associated with diabetic peripheral neuropathy.25-(OH) D level seems to be an independent risk factor of diabetic neuropathy in patients with type 2 diabetes mellitus.