Association between the efficacy of alendronate and serum level of vitamin D in patients with osteoporosis
10.3760/cma.j.issn.1000-6699.2014.04.008
- VernacularTitle:阿仑膦酸钠疗效与维生素D血清水平的相关性
- Author:
Ling PAN
;
Li YOU
;
Yongde PENG
;
Jinyu CHEN
;
Lin CHEN
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Alendronate;
Biphosphonates;
Vitamin D
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(4):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the association between vitamin D and alendronate response,and to investigate the proper vitamin D levels for the efficacy of alendronate treatment of osteoporosis.Methods In this retrospective study,559 post-menopausal women with osteoporosis were devided into two groups:non-responders and responders,based on the European Study of Forsteo (EUROFORS).Demographic and clinical data including mean 25-hydroxy vitamin D (25-OHD) levels between dual-energy X-ray absorptiometry (DEXA) scans were obtained.Mean 25-OHD levels were compared between responders and non-responders and multiple logistic regression analysis was performed to identify factors associated with non-response.Results There were 437 (75.5％) responsers to alendronate therapy and 142 (24.5％) non-responders.Responders with a mean serum 25-OHD level of (59.96 ±12.56) nmol/L,obtained a more favorable result than non-responders,whose serum 25-OHD level was (47.50 ±9.92) nmol/L (P＜0.01).25-OHD level was significantly associated with response.Conclusion Patients with a mean 25-OHD ≥50 nmol/L had a substantially greater likelihood of maintaining bisphosphonate response.
