The correlation of serum YKL-40 level and albuminuria in type 2 diabetes

VernacularTitle:2型糖尿病患者血清YKL-40水平与尿白蛋白的相关性
Author: Jinyu HAN ; Ying SHAO ; Qiuyue WANG
Publication Type:Journal Article
Keywords: Diabetic nephropathy; YKL-40; Albuminuria
From: Chinese Journal of Endocrinology and Metabolism 2014;30(3):225-227
CountryChina
Language:Chinese
Abstract: A total of 175 patients with type 2 diabetes mellitus (T2DM) were composed of 69 with normoalbuminuria,60 with microalbuminuria,and 46 with macroalbuminuria.The control group consisted of 64 healthy individuals.Serum YKL-40 levels were determined with ELISA method and related metabolic data were collected.Serum YKL-40 levels were significantly higher in T2DM group than in control group(P＜0.01).Significant correlations of YKL-40 were found with the ratio of microalbuminuria to uric creatinine(r=0.677,P＜0.01),HbA1C (r =0.562,P＜0.01),systolic blood pressure (r =0.372,P =0.001),HOMA-IR (r =0.460,P =0.001),low density lipoprotein-cholesterol (r=0.304,P=0.012),age(r=0.260,P=0.015),blood uric acid (r=0.329,P=0.018),and high density lipoprotein-cholesterol (r=-0.247,P=0.032).YKL-40 may play a role in the occurrence and development of diabetic nephropathy.