A meta-analysis of the association between thyroglobulin gene polymorphism and autoimmune thyroid disease
10.3760/cma.j.issn.1000-6699.2014.03.012
- VernacularTitle:甲状腺球蛋白基因多态性与自身免疫性甲状腺疾病易感性的meta分析
- Author:
Jia LIU
;
Yuan XU
;
Xia GAO
;
Zhi YAO
;
Pengrui ZHANG
;
Guang WANG
- Publication Type:Journal Article
- Keywords:
Thyroglobulin;
Autoimmune thyroid disease;
Gene polymorphism
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(3):221-224
- CountryChina
- Language:Chinese
-
Abstract:
The association between thyroglobulin gene polymorphism and autoimmune thyroid disease was investigated.A total of eight case-control studies were included.E33SNP was associated with increased susceptibility of autoimmune thyroid disease in recessive model (OR =1.54,95 ％ CI 1.21 ～ 1.97,P =0.024),while E12SNP was associated with increased susceptibility of autoimmune thyroid disease in allele model (OR =1.12,95％ CI 1.05 ～1.21,P =0.033).Thyroglobulin gene polymorphism seems to be associated with autoimmune thyroid disease.
