Serum nesfatin-1 levels in gestational diabetes mellitus in relation to insulin resistance and pancreatic β-cell function
10.3760/cma.j.issn.1000-6699.2014.03.008
- VernacularTitle:妊娠糖尿病患者血清Nesfatin-1与胰岛素抵抗及胰岛细胞功能的相关性研究
- Author:
Lu DING
;
Honglin HU
;
Fang DAI
;
Rong XUAN
;
Changjiang WANG
- Publication Type:Journal Article
- Keywords:
Nesfatin-1;
Gestational diabetes mellitus;
Insulin resistance;
Islet β-cell function
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
The association of serum nesfatin-1 levels with insulin resistance and pancreatic β-cell function in gestational diabetes mellitus was investigated.Oral glucose tolerance test(OGTT) was performed in ninety pregnant women from 24,to 28 gestational weeks.They were divided into three groups according to OGTT:45 nomal controls,27 gestational diabetes mellitus with fasting plasma glucose (FPG) of 5.1 mmol/L to 7.0 mmol/L (GDM1),18 gestational diabetes mellitus with FPG more than 7.0 mmol/L (GDM2).Serum nesfatin-1 levels were significantly higher in patients with GDM1 and GDM2 than in controls (P＜0.01),and in GDM2 group it was also higher than GDM1 group(P＜0.05).Fasting serum nesfatin-1 was positively correlated with FPG,30 min plasma glucose,1 h plasma glucose,2 h plasma glucose,homeostasis model assessment for insulin resistance,and PGAUC,but negatively correlated with homeostasis model assessment for β-cell function.Furthermore,multiple stepwise regression analysis showed that FPG was the independent influencing factor of serum nesfatin-1 level.Nesfatin-1 was positively correlated with insulin resistance,while negatively correlated with pancreatic β-cell function.Nesfatin-1 may play a role in the pathogenesis of gestational diabetes mellitus.
