On the relationship between bone mineral density and bone turnover markers in subjects aged 80 and above

VernacularTitle:80岁以上高龄老人骨密度与骨转换标志物的相关性研究
Author: Pingda BIAN ; Qifeng YING ; Xiuyang LI ; Jinping CHEN
Publication Type:Journal Article
Keywords: Bone mineral density; Bone turnover marker
From: Chinese Journal of Endocrinology and Metabolism 2014;30(3):206-209
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of bone turnover markers(BTMs) in forecasting the variance of bone mineral density (BMD) by studying the relationships between BTMs and BMD in persons aged 80 and above.Methods A sample of 1 509 subjects aged 80 and above was recruited.All subjects underwent BMD measurement by dual energy X-ray absorptiometry,and BTMs (C-telopeptide of type 1 collagen,N-terminal propeptide of type 1 procolagen,osteocalcin) measurements.The relationships among all the BTMs,and between BMD and BTMs were analysed.Results In subjects aged 80 and above,the relationships among BTMs were moderately positive(all P＜0.05).In men aged 80 and above,BMDs were inversely associated with BTMs(all P＜0.05),and in women,BMDs were inversely associated with osteocalcin (P＜ 0.05).Conclusions The clinical significance of BTMs in persons aged 80 and above indicates bone resorption when BTMs are raised.In men aged 80 and above any of BTMs may be selected to evaluate bone metabolism ; while in women,osteocalcin should be selected.