Clinical research of impulse GnRH infusion treatment to a patient with central secondary amenorrhea
10.3760/cma.j.issn.1000-6699.2014.03.005
- VernacularTitle:促性腺激素释放激素皮下微量脉冲输注治疗中枢性继发性闭经一例临床研究
- Author:
Shouyue SUN
;
Huiying JIA
;
Wei ZHU
;
Yihong JIANG
;
Weiqing WANG
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Pituitary hormone pump;
GnRH impulse therapy;
Secondary amenorrhea;
Pregnancy;
Assisted reproductive technology;
In vitro fertilization
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(3):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To apply continuous subcutaneous pulse infusion of gonadotropin-releasing hormone (GnRH) to treat patients with central secondary amenorrhea,and to observe the induction of spontaneous ovulation and natural fertilization.Methods Using micro-pulse infusion pumps with each 90-minute infusion of LHRH 10 μg daily,the serum LH,FSH,estrogen,and progesterone levels ; and change in endometrium and ovarian size before and after treatment were monitored.The end point is natural pregnancy.Results The levels of serum LH,FSH,and estrogen were obviously increased after 4 weeks of treatment.The natural menstrual cycle was rebuilt after 8 weeks of treatment.The patient was pregnant and the treatment was stopped by 16 weeks.The experience of pregnancy was favourable.40 weeks later,the patient delivered a healthy female infant via caesarean section.Conclusions It was the first time in China that the technology of micro GnRH pump was applied in patients with secondary central amenorrhea.The result demonstrates that this technology can perfectly simulate the physiology of hypothalamic GnRH secretion.At present,more patients are included in this research to confirm the effectiveness.
